https://www.ceesdekker.net - An Overview
https://www.ceesdekker.net - An Overview
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Rotary movement of DNA rotors on nanopores. Leading row: Uncooked movie from the Cy5 channel of each and every rotor. Middle row: corresponding one-particle localization benefits of each finishes in the DNA rotors. The posture of the current body is marked as orange and blue dots, along with the trajectory of the 10 frames ahead of the current body is shown as stable lines.
1996, initially mesoscopic charge density waves units; and to start with electrical measurements on just one steel nanocluster concerning nanoelectrodes
Like a individual, I possess the biblical assignment to check out and use all the things in creation for the benefit of my neighbour. I tend not to working experience any conflict in between faith and science. On the contrary, my religion stimulates me to try and do science, to be open-minded on earth.’
I am able to rarely consider how I, being a geneticist, would be capable to understand basic physics, let alone contend at the highest. How did you go about this?
We develop place-of-care diagnostics check of neglected tropical diseases in just source-restricted settings, dependant on Crspr/Cas9 detecting of pathogen’s DNA in human body fluids.
SMC complexes can go Actual physical roadblocks bigger than their ring dimension, indicating a nontopological mechanism for DNA loop extrusion
Length Charge of particular person carbon nanotubes by nanostructuring Along with the scanning tunneling microscope
Dynamic ParB–DNA interactions initiate and retain a partition condensate for bacterial chromosome segregation
What if, in lieu of employing standard top rated-down silicon electronics, transistors could possibly be crafted from the bottom up applying solitary natural and organic molecules since the switching elements? This concept, which turned The idea of now’s area of molecular electronics, to start with emerged inside the nineteen seventies.
Resolving the action dimensions in condensin-pushed DNA loop extrusion identifies ATP binding as being the phase-making approach
An built-in microfluidic System for quantifying drug permeation throughout biomimetic vesicle membranes
Several new phenomena were uncovered, and he and his analysis team recognized a leading situation Within this industry of analysis. Dekker and his research group discovered new physics of nanotubes and also explored the feasibility of molecular electronics. In 1998, they were the 1st to construct a transistor based upon just one nanotube molecule.
As an example, we look at the nucleopore advanced, a gateway involving the cell nucleus and the cytoplasm. This is a really challenging method and therefore challenging to review within a mobile, so we use biomimetics. We reconstruct ceesdekker.net holes and afterwards insert personal elements with the nucleopore sophisticated to study transportation via it at The one-molecule degree.’
It was an incredibly attention-grabbing time, throughout which I gained loads of assistance from Delft University of Know-how, where I was a professor at enough time, And that i begun a number of collaborations with molecular biologists. That assisted me understand lots.’