Considerations To Know About ceesdekker
Considerations To Know About ceesdekker
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Utilizing one-molecule optical and AFM imaging and pressure-spectroscopy approaches, we find to unravel the mechanistic elements of the structure and dynamics of chromosomes. Our exploration passions consist of:
It was only while in the 1990s however, when nanotechnology experienced Superior to the degree where by single molecules may very well be manipulated, that the very first experimental products began to seem.
[Laughs] ‘It absolutely was unquestionably an awesome hazard! At enough time, I used to be effectively mindful that it could go Improper and that I could become significantly less thriving, but I just overlooked that. Curiosity has constantly been my strongest driving power. And fortunately it all worked out.’
Because 2000, Dekker has shifted the leading concentrate of his get the job done to biophysics exactly where he reports the Attributes of single biomolecules and cells using the equipment of nanotechnology. This alteration of field was driven by his fascination for the impressive operating of Organic molecular buildings, as well as with the extensive-term perspective that lots of interesting discoveries can be expected In this particular field.[5] Current lines of analysis in his biophysics group are inside the regions of:[six]
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Experimental phase diagram of negatively supercoiled DNA calculated by magnetic tweezers and fluorescence,
MATLAB codes for data processing can be obtained at . Julia codes used for numerical simulation are offered at .
Atomic drive microscopy shows that vaccinia topoisomerase IB generates filaments on DNA in the cooperative fashion
2003, shown the 1st biosensors manufactured from a carbon nanotube; settled the structure and system of DNA mend proteins; and discovery of a whole new approach for fabricating strong-point out nanopores for DNA translocation
Dekker started his investigate on solitary carbon nanotubes in 1993 when he set up a completely new line of investigation to study electrical transportation by means of one organic and natural molecules in between nanoelectrodes. In 1996 a breakthrough was understood with carbon nanotubes. This was attained inside of a collaboration Along with the group of Nobel laureate Richard Smalley. STM and nanolithography techniques were being used to show that these nanotubes are quantum wires at The one-molecule degree, with outstanding Bodily properties.
Because 2000 he moved to one-molecule biophysics and nanobiology, with study from experiments of DNA loop extrusion and supercoiling to DNA translocation by way of nanopores. Much more not long ago his analysis has centered on learning chromatin composition and cell division with micro organism on chip, although he is usually trying to finally Construct artificial cells from the bottom up.
Nanoscientist Cees Dekker is definitely an amiable and flamboyant man who seems Substantially more youthful compared to the 62 yrs he in fact is – trendy Eyeglasses, psychedelic shirt, participating cees dekker smile – but not one to squander time. He normally takes his time, but no more than vital.
2008, first observation of protein-coated DNA translocation through nanopores; fixed the origin of your electrophoretic drive on DNA in nanopores; learned a big velocity enhance of microtubules in electrical fields; found an anomalous electro-hydrodynamic orientation of microtubules; and resolved the origin of sounds in carbon nanotubes in liquid
2013, managed shaping of live bacterial cells into arbitrary designs; and discovery of spontaneous fluctuations in the handedness of histone tetrasomes